Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively.
説明 | NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively. |
In vitro | NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1]. |
分子量 | 337.3 |
分子式 | C18H12FN3O3 |
CAS No. | 714240-31-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.3 mg/mL (18.7 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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NCGC00029283 714240-31-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis NCGC 00029283 NCGC-00029283 Inhibitor inhibitor inhibit