store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 60,500 |
5 mg | 在庫あり | ¥ 181,000 |
10 mg | 在庫あり | ¥ 289,500 |
25 mg | 在庫あり | ¥ 429,500 |
50 mg | 在庫あり | ¥ 581,000 |
100 mg | 在庫あり | ¥ 778,000 |
説明 | NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23. |
In vitro | NDI-034858 (compound I-908) (10 μM) demonstrates inhibitory activity against Tyk2 and JAK enzymes. It achieves this by targeting the Tyk2 JH1 domain and the JAK JH1 domain, resulting in inhibition rates of less than 50% for both enzymes.[2] |
別名 | TAK-279, NDI-03485 |
分子量 | 460.49 |
分子式 | C23H24N8O3 |
CAS No. | 2272904-53-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (97.7 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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NDI-034858 2272904-53-5 Immunology/Inflammation Tyrosine Kinase/Adaptors Tyrosine Kinases IL Receptor NDI03485 NDI 034858 TAK279 TAK 279 TAK-279 NDI 03485 NDI034858 NDI-03485 Inhibitor inhibitor inhibit