Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.PARP-1-IN-2 induced apoptosis in A549 cells.
説明 | PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.PARP-1-IN-2 induced apoptosis in A549 cells. |
ターゲット&IC50 | PARP1:149 ± 11.0 nM |
In vitro |
PARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) significantly anti-proliferative activity against A549 cells and didn’t display any significant cytotoxicity on HFF cells.[1] PARP-1-IN-2 (0-10 μM, 24 h) decreases the expression of pro-caspase-3 and phosphorylated AKT increases the expression of caspase-3, caspase-9 protein, and the cleaved PARP-1.[1] |
分子量 | 424.28 |
分子式 | C22H15Cl2N3O2 |
CAS No. | 684234-55-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75.0 mg/mL (176.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PARP-1-IN-2 684234-55-7 Chromatin/Epigenetic DNA Damage/DNA Repair PARP Inhibitor inhibitor inhibit