Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with IC50 values under 0.3 nM [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 349,000 |
50 mg | 約8-10 週間 | ¥ 454,500 |
100 mg | 約8-10 週間 | ¥ 574,000 |
説明 | PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with IC50 values under 0.3 nM [1]. |
ターゲット&IC50 | PARP1:0.6 nM |
In vitro | PARP1-IN-14 (compound 19k) significantly inhibits the proliferation of drug-resistant Capan-1 cells (IC 50 < 0.3 nM) [1]. Treatment with PARP1-IN-14 (0-1 μM for 24 hours) induces DNA damage in both the parent Capan-1 (BRCA2 −/−) and the drug-resistant Capan-1 cells [1]. Additionally, PARP1-IN-14 (0-1 μM for 0-48 hours) triggers cell cycle arrest and apoptosis in both the parental and resistant cells [1]. |
分子量 | 525.53 |
分子式 | C28H24FN7O3 |
CAS No. | 2098639-70-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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PARP1-IN-14 2098639-70-2 Chromatin/Epigenetic DNA Damage/DNA Repair PARP Inhibitor inhibitor inhibit