Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 7,500 | |||
10 mg | 在庫あり | ¥ 11,500 | |||
25 mg | 在庫あり | ¥ 21,500 | |||
50 mg | 在庫あり | ¥ 35,500 | |||
100 mg | 在庫あり | ¥ 57,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 8,000 |
説明 | UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1. |
ターゲット&IC50 | PARP2:0.3 μM |
In vitro | UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM. [1] |
In vivo | In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage. [1] |
分子量 | 279.29 |
分子式 | C17H13NO3 |
CAS No. | 1048371-03-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.9 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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UPF 1069 1048371-03-4 Chromatin/Epigenetic DNA Damage/DNA Repair PARP UPF1069 inhibit Inhibitor poly ADP ribose polymerase UPF-1069 inhibitor