keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PMX-53, a macrocyclic complement 5a (C5a) peptidomimetic and C5a receptor antagonist (IC50 = 0.3 µM), effectively inhibits the C5a-induced secretion of myeloperoxidase (MPO) in isolated human polymorphonuclear leukocytes (PMNs). Administered orally at 10 mg/kg, PMX-53 mitigates vascular leakage, PMN infiltration, and the production of TNF-α and IL-6 in a rat peritoneal Arthus reaction model. Additionally, in a 3-nitropropionic acid (3-NP)-induced Huntington’s disease rat model, it alleviates body weight loss, anorexia, and striatal degeneration. Furthermore, at a dose of 3 mg/kg, PMX-53 decreases atherosclerotic lesion size and lipid content in ApoE-/- mice.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 34,500 |
5 mg | 約 35 days | ¥ 128,000 |
10 mg | 約 35 days | ¥ 187,000 |
25 mg | 約 35 days | ¥ 340,000 |
説明 | PMX-53, a macrocyclic complement 5a (C5a) peptidomimetic and C5a receptor antagonist (IC50 = 0.3 µM), effectively inhibits the C5a-induced secretion of myeloperoxidase (MPO) in isolated human polymorphonuclear leukocytes (PMNs). Administered orally at 10 mg/kg, PMX-53 mitigates vascular leakage, PMN infiltration, and the production of TNF-α and IL-6 in a rat peritoneal Arthus reaction model. Additionally, in a 3-nitropropionic acid (3-NP)-induced Huntington’s disease rat model, it alleviates body weight loss, anorexia, and striatal degeneration. Furthermore, at a dose of 3 mg/kg, PMX-53 decreases atherosclerotic lesion size and lipid content in ApoE-/- mice. |
別名 | AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg], AcF-[OPdChaWR], 3D53 |
分子量 | 896.09 |
分子式 | C47H65N11O7.XCF3COOH |
CAS No. | 514814-99-4 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
You can also refer to dose conversion for different animals. 詳細
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PMX-53 TFA 514814-99-4 AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg] AcF-[OPdChaWR] 3D53 Inhibitor inhibitor inhibit