store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 7,500 |
5 mg | 在庫あり | ¥ 13,500 |
50 mg | 約5 days | ¥ 45,500 |
100 mg | 約5 days | ¥ 81,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 24,500 |
説明 | PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM. |
ターゲット&IC50 | HSP90:51 nM |
In vitro | PU-H71(1 μ M) potently inhibits the growth of triple negative breast cancer (TNBC) cell lines MDA-MB-468, MDA-MB-231, and HCC-1806, with IC50 values of 65, 140, and 87 nM, respectively. PU-H71(1 μ M) kills 80%, 65%, and 80% of MDA-MB-468, MDA-MB-231, and HCC-1806 cells, respectively[1]. |
In vivo | MDA-MB-231 model treated with PU-H71 at a dose of 75 mg/kg was 100% fully effective. After 37 days of treatment, tumor was replaced by scar tissue, accompanied by a reduction in many proliferative and anti apoptotic molecules, such as EGFR, HER3, Raf-1, Akt, and p-Akt, which decreased by 80%, 95%, 99%, 80%, and 65%, respectively. PU-H71 (75 mg/kg, three times a week) inhibits tumor growth by 96%, reduces tumor cell proliferation by 60%, decreases activated Akt associated with survival and high invasive potential by 85%, and increases apoptosis by 6-fold[1]. |
分子量 | 512.37 |
分子式 | C18H21IN6O2S |
CAS No. | 873436-91-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 46.1 mg/mL (89.9 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PU-H71 873436-91-0 Cytoskeletal Signaling Metabolism HSP PUH71 PU H71 Inhibitor inhibitor inhibit