Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 24,000 | |||
10 mg | 在庫あり | ¥ 37,500 | |||
25 mg | 在庫あり | ¥ 72,000 | |||
50 mg | 在庫あり | ¥ 114,000 | |||
100 mg | 在庫あり | ¥ 186,500 | |||
500 mg | 在庫あり | ¥ 374,000 |
説明 | GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM). |
In vitro | GRP78-IN-3 (0.1-100 μM) shows more potent inhibition efffects in a spheroid tumor model (U251 glioblastoma cells and H520 lung cancer cells) [1]. |
分子量 | 342.42 |
分子式 | C17H18N4O2S |
CAS No. | 2707510-30-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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GRP78-IN-3 2707510-30-1 Cytoskeletal Signaling Metabolism HSP GRP78IN3 Inhibitor inhibitor inhibit