store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 52,500 |
2 mg | 在庫あり | ¥ 79,000 |
5 mg | 在庫あり | ¥ 132,000 |
10 mg | 在庫あり | ¥ 189,000 |
25 mg | 在庫あり | ¥ 333,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 603,500 |
説明 | PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars. |
In vitro | PXS-6302 hydrochloride exhibits high permeability in monolayer cells, such as Caco-2 or MDCKII cells[1]. |
In vivo |
PXS-6302 hydrochloride inhibits LOX, reduces cross-linking, and improves the appearance of scars in porcine excision and burn models[1]. In a mouse injury model, topical application of PXS-6302 hydrochloride (1.5%, water-in-oil cream; 500 mg cream applied to 16 cm2; topical; once daily for 28 days) reduces collagen deposition and cross-linked proteins in the fibrotic tissue[1]. Additionally, PXS-6302 hydrochloride (0.5%, 1.5%, or 3%, water-in-oil ointment; 400 mg ointment applied to 16 cm2; topical; once daily for 12 weeks) significantly improves the appearance of scars without reducing tissue strength in a porcine injury model under local application[1]. |
別名 | PXS-6302 hydrochloride (2584947-54-4 Free base) |
分子量 | 301.71 |
分子式 | C10H11ClF3NO2S |
CAS No. | 2584947-79-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (165.72 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PXS-6302 hydrochloride 2584947-79-3 Metabolism Lipoxygenase PXS6302 Hydrochloride 2584947-54-4 Free base PXS-6302 Hydrochloride 2584947-54-4 PXS-6302 hydrochloride (2584947-54-4 Free base) PXS 6302 Hydrochloride Inhibitor inhibitor inhibit