Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 153,000 |
5 mg | 在庫あり | ¥ 319,000 |
10 mg | 在庫あり | ¥ 434,000 |
25 mg | 在庫あり | ¥ 649,500 |
50 mg | 在庫あり | ¥ 877,000 |
100 mg | 在庫あり | ¥ 1,182,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 365,000 |
説明 | RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter. |
In vitro | RJW100 (compound 24-exo) treatment induces a significant dose-dependent increase in small/short heterodimer partner (SHP) transcripts beginning at 5 µM. RJW100 (compound 24-exo) clearly displaces the bound PIP2 phospholipid from SF-1 almost completely at 1 µM. Using hLRH-1 LBD alone that had not been complexed with any phospholipids, the result shows a clear dose-dependent shift in hLRH-1 LBD (ligand binding domain) native PAGE migration upon RJW100 (compound 24-exo; 0-100 µM) binding[1]. RJW100 causes strong activation of the miR-200c promoter and exhibits strong ability to downregulate ZEB1 and ZEB2 proteins[2]. |
分子量 | 386.57 |
分子式 | C28H34O |
CAS No. | 1276664-20-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (142.27 mM)
You can also refer to dose conversion for different animals. 詳細
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RJW100 1276664-20-0 Others RJW 100 RJW-100 Inhibitor inhibitor inhibit