keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microglia function. Sematimod tetrahydrochloride inhibits TLR4 signaling, TNF-α, IL-1β, and IL-6, and is used in the study of Crohn's disease and other inflammatory conditions.
説明 | Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microglia function. Sematimod tetrahydrochloride inhibits TLR4 signaling, TNF-α, IL-1β, and IL-6, and is used in the study of Crohn's disease and other inflammatory conditions. |
In vivo | In male OZ rats, Semapimod tetrahydrochloride (5 mg/kg; i.p.; once daily for 2 weeks) restored endothelium-dependent vasorelaxation[1]. |
別名 | CPSI-2364 tetrahydrochloride |
分子量 | 890.74 |
分子式 | C34H56Cl4N18O2 |
CAS No. | 164301-51-3 |
keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1 mg/mL (1.12 mM), Sonication is recommended.
H2O: 1 mg/mL (1.12 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Semapimod tetrahydrochloride 164301-51-3 Immunology/Inflammation MAPK TLR Semapimod CPSI-2364 tetrahydrochloride Inhibitor inhibitor inhibit