Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 10,500 | |||
10 mg | 在庫あり | ¥ 16,500 | |||
25 mg | 在庫あり | ¥ 33,500 | |||
50 mg | 在庫あり | ¥ 49,500 | |||
100 mg | 在庫あり | ¥ 74,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
In vitro | Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3] |
In vivo | Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94 mg/kg (i.v.) [4] |
植物由来 |
分子量 | 246.35 |
分子式 | C15H22N2O |
CAS No. | 6483-15-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 49 mg/mL (198.9 mM)
H2O: 5 mg/mL(20.30 mM)
DMSO: 49 mg/mL (198.9 mM)
You can also refer to dose conversion for different animals. 詳細
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Sophocarpine 6483-15-4 Angiogenesis Immunology/Inflammation JAK/STAT signaling MAPK Neuroscience NF-Κb Stem Cells Tyrosine Kinase/Adaptors ERK p38 MAPK HER COX TLR NF-κB JNK STAT Apoptosis Influenza Virus PI3K Phosphoinositide 3-kinase Inhibitor Autophagy PKB Akt Protein kinase B inhibit inhibitor