Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin. The compound also promotes apoptosis and exhibits anti-proliferative effects on human leukemia cell lines [1].
説明 | Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin. The compound also promotes apoptosis and exhibits anti-proliferative effects on human leukemia cell lines [1]. |
In vitro | Sirt1/2-IN-2 (compound hsa55) at a concentration of 5 μM over 48 hours induces apoptosis in various tumor cell lines, with IC50 values of 13 μM for MV4-11, 11.5 μM for MOLM-13, 34.4 μM for THP1, and 27.5 μM for Jurkat cells [1]. Additionally, at 100 μM for 30 minutes, Sirt1/2-IN-2 reduces the thermal stability of SIRT1 and SIRT2 proteins at different temperatures. At concentrations of 25 μM and 30 μM over 24 hours, the compound increases the levels of acetylated p53 and α-tubulin in MOLM-13 cells [1]. |
分子量 | 398.46 |
分子式 | C18H14N4O3S2 |
CAS No. | 670267-73-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Sirt1/2-IN-2 670267-73-9 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor inhibitor inhibit