Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 15,000 | |||
5 mg | 在庫あり | ¥ 29,000 | |||
10 mg | 在庫あり | ¥ 49,500 | |||
25 mg | 在庫あり | ¥ 104,500 |
説明 | AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively). |
In vitro | AGK2 is a selective SIRT2 inhibitor with IC50 value of 3.5 μM. AGK2 slightly inhibited SIRT1 and 3 only at concentrations over 40 μM. Relative to an inactive control AGK7, AGK2 increased acetylated tubulin. In H4 cells transfected with α-Syn, AGK2 reduced α-Syn-mediated toxicity in a dose-dependent way. By contrast, the inactive AGK7 had no effect. In H4 cells cotransfected withα-Syn and synphilin-1, the inactive AGK7 failed to affect a-Syn aggregation, whereas AGK2 promoted the formation of enlarged inclusions [1]. |
分子量 | 434.27 |
分子式 | C23H13Cl2N3O2 |
CAS No. | 304896-21-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 0.5 mg/mL
You can also refer to dose conversion for different animals. 詳細
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AGK7 304896-21-7 Chromatin/Epigenetic DNA Damage/DNA Repair Others Sirtuin Parkinson's disease sirtuin 2 morphology SIRT2 Inhibitor,Inactive Control Drosophila inhibit toxicity Inhibitor alpha-synuclein dopaminergic cell death AGK 7 AGK-7 inhibitor