store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-71 can be used as a kinase probe with anticancer activity and inhibits the proliferation of various cancer cell lines.
説明 | SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-71 can be used as a kinase probe with anticancer activity and inhibits the proliferation of various cancer cell lines. |
ターゲット&IC50 | GAK:0.8 nM, MAPK3:107 nM, SRC:2 nM, MAPK1:48.3 nM, MAP3K1:28.7 nM, MAP2K1:10.4 nM, LIMK1:5.4 nM, YES1:0.8 nM, BMP2K:7.1 nM, MAP2K2:9.3 nM, AAK1:4.4 nM |
In vitro | Potently inhibiting the proliferation of H23 and Calu-6 non-small cell lung cancer cell lines in a concentration-dependent manner, SM1-71 (0.001-100 μM; 72 h) demonstrates its efficacy. Additionally, SM1-71 induces potent cytotoxicity within 72 hours, with nanomolar values for GR50 and negative GRmax values observed in eight of 11 cancer cell lines[1][2]. |
分子量 | 463.96 |
分子式 | C24H26ClN7O |
CAS No. | 2088179-99-9 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (215.54 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SM1-71 2088179-99-9 Cell Cycle/Checkpoint MAPK Metabolism Neuroscience Stem Cells AAK1 (AP2 associated kinase 1) TGF-beta/Smad LIM Kinase Serine/threonin kinase SM-1-71 SM171 SM1 71 Inhibitor inhibitor inhibit