Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in a rat model of pulmonary hypertension [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in a rat model of pulmonary hypertension [1]. |
In vivo | Smurf1-IN-1 (Compound 38), when administered orally at doses of 1, 3, and 10 mg/kg, significantly ameliorates the condition of a rat model of pulmonary hypertension [1]. Pharmacokinetic profiling of Smurf1-IN-1 reveals a half-life (T 1/2) of 7.9 hours with intravenous administration of 1 mg/kg, and an oral bioavailability (F%) of 82% at a 3 mg/kg dosage [1]. |
分子量 | 468.98 |
分子式 | C24H29ClN6O2 |
CAS No. | 1824708-03-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Smurf1-IN-1 1824708-03-3 Ubiquitination E1/E2/E3 Enzyme Inhibitor inhibitor inhibit