Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo.
説明 | NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo. |
In vitro | NAE-IN-M22 as a selective NAE inhibitor. M22 is reversible for NAE, inhibits multiple cancer cell lines with GI50 values in the low micromolar range, and induces apoptosis in A549 cells. |
In vivo | NAE-IN-M22 as a selective NAE inhibitor. M22 is reversible for NAE, inhibits multiple cancer cell lines with GI50 values in the low micromolar range, and induces apoptosis in A549 cells. |
別名 | NEDD8 inhibitor M22 |
分子量 | 363.32 |
分子式 | C20H24Cl2N2 |
CAS No. | 864420-54-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (688.10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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NAE-IN-M22 864420-54-2 Apoptosis Ubiquitination E1/E2/E3 Enzyme NAEINM22 cancer Inhibitor NAE-IN-M-22 NAE NEDD8 NAE IN M22 enzyme activating inhibit NEDD8 inhibitor M22 tumor inhibitor