Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively. It disrupts redox homeostasis through ROS generation, consequently enhancing p21 protein stability and inducing mitochondrial dysfunction. Furthermore, this compound significantly impedes cell cycle progression and malignancy proliferation, while also activating the Nrf2 signaling pathway [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively. It disrupts redox homeostasis through ROS generation, consequently enhancing p21 protein stability and inducing mitochondrial dysfunction. Furthermore, this compound significantly impedes cell cycle progression and malignancy proliferation, while also activating the Nrf2 signaling pathway [1]. |
ターゲット&IC50 | SIRT1:1.13 μM, SIRT3:5.41 μM |
In vitro | SPC-180002 (0-5 µM, 24 hours) inhibits cell cycle progression via accumulation of p21, leading to subsequent cellular senescence [1]. Moreover, SPC-180002 does not induce apoptosis or autophagy [1]. |
In vivo | SPC-180002 (1-5mg/kg, bi-weekly, intraperitoneally) can inhibit the growth of various cancer cells and impede tumor growth in MCF7 xenograft mice [1]. |
分子量 | 317.38 |
分子式 | C18H23NO4 |
CAS No. | 2170274-53-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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SPC-180002 2170274-53-8 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor inhibitor inhibit