store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 13,500 | |||
5 mg | 在庫あり | ¥ 32,000 | |||
10 mg | 在庫あり | ¥ 58,500 | |||
25 mg | 在庫あり | ¥ 118,000 | |||
50 mg | 在庫あり | ¥ 167,000 | |||
100 mg | 在庫あり | ¥ 226,000 | |||
500 mg | 在庫あり | ¥ 452,500 |
説明 | SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response. |
In vitro | SRI-42127 (0.05-1 μM; 24 h) inhibits HuR translocation in LPS-activated glial cells in vitro and significantly attenuates the production of pro-inflammatory mediators, including IL1β, IL-6, TNF-α, iNOS, CXCL1 and CCL2[1]. |
In vivo | SRI-42127 (15 mg/kg; intraperitoneal injection; single dose) inhibits in vivo microglial activation and attenuates neutrophil and monocyte recruitment/chemotaxis[1]. |
分子量 | 348.4 |
分子式 | C19H20N6O |
CAS No. | 2727872-68-4 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (86.11 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SRI-42127 2727872-68-4 Chromatin/Epigenetic HuR Inhibitor inhibitor inhibit