Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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500 mg | 在庫あり | ¥ 11,000 | |||
1 g | 在庫あり | ¥ 15,500 | |||
5 g | 在庫あり | ¥ 35,500 | |||
10 g | 在庫あり | ¥ 60,500 |
説明 | Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats. |
In vivo | Tempone (100 mg/kg i.v. bolus followed by 30 mg/kg i.v. infusion; rats) significantly improved both glomerular and tubular function (serum urea, creatinine, creatinine clearance, and fractional excretion of Na(+)) in a dose-dependent manner and significantly attenuated the reperfusion-injury associated with I/R (urinary N-acetyl-beta-D-glucosaminidase, aspartate aminotransferase, assessment of renal histology). Tempone also markedly reduced the immunohistochemical evidence of the formation of nitrotyrosine and poly(ADP-ribose), indicating a reduction of nitrosative and oxidative stress, respectively. Importantly, in contrast to its in vivo metabolite TEMPOL (which also provided protective effects against renal I/R and oxidative stress of PT cells), Tempone reduced renal dysfunction and injury without causing a significant reduction in blood pressure upon administration. These results suggest, for the first time, that Tempone can reduce the renal dysfunction and injury caused by I/R and the injury caused to PT cells by oxidative stress without producing the adverse cardiovascular effects observed when using other nitroxyl radicals.[2] |
別名 | 4-Oxo-tempo |
分子量 | 170.23 |
分子式 | C9H16NO2 |
CAS No. | 2896-70-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (264.35 mM)
PBS (pH 7.2): 10 mg/mL
DMF: 30 mg/mL
Ethanol: 30 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Tempone 2896-70-0 4-Oxo-tempo Inhibitor inhibitor inhibit