Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM. It amplifies the cytotoxic impact of cytidine analogues on leukemia cells and exhibits potential against COVID-19 by modulating SARS-CoV-2 interactors.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 12,500 | |||
5 mg | 在庫あり | ¥ 29,500 | |||
10 mg | 在庫あり | ¥ 49,000 | |||
25 mg | 在庫あり | ¥ 98,000 | |||
50 mg | 在庫あり | お問い合わせ |
説明 | TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM. It amplifies the cytotoxic impact of cytidine analogues on leukemia cells and exhibits potential against COVID-19 by modulating SARS-CoV-2 interactors. |
ターゲット&IC50 | TPase:47 nM (IC50) |
In vitro | TH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%). TH1217 presents suitable mouse microsomal half-lives (109 minutes). TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition[1]. |
別名 | TH 1217 |
分子量 | 491.09 |
分子式 | C20H17BCl2N4O6 |
CAS No. | 1862212-48-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 117 mg/mL (238.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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TH1217 1862212-48-3 Others TH-1217 TH 1217 Inhibitor inhibitor inhibit