Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TMX-4153 is a bivalent degrader that selectively targets and rapidly degrades endogenous PIP4K2C through recruitment of the von Hippel-Lindau (VHL) E3 ligase complex, demonstrating a K D of 42 nM. It is applicable in the synthesis of PROTAC [1].
説明 | TMX-4153 is a bivalent degrader that selectively targets and rapidly degrades endogenous PIP4K2C through recruitment of the von Hippel-Lindau (VHL) E3 ligase complex, demonstrating a K D of 42 nM. It is applicable in the synthesis of PROTAC [1]. |
In vitro | TMX-4153, at concentrations of 0.01, 0.05, 0.1, 0.5, and 1 µM and with an exposure duration of 6 hours, selectively degrades PIP4K2C in MOLT-4 cells [1]. |
分子量 | 1079.75 |
分子式 | C59H67ClN10O6S |
CAS No. | 2867519-91-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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TMX-4153 2867519-91-1 PROTAC Ligands for Target Protein for PROTAC Inhibitor inhibitor inhibit