Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
説明 | AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. |
ターゲット&IC50 | Androgen receptor: |
In vitro | AR antagonist 1 (compound 29) is the ligand for the target ligase of ARD-266. ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. AR antagonist 1 exhibits micromolar binding affinity to its E3 ligase complex, it can be successfully employed for the design of highly potent and efficient PROTAC degraders. |
分子量 | 278.78 |
分子式 | C15H19ClN2O |
CAS No. | 1818885-54-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (215.22 mM)
You can also refer to dose conversion for different animals. 詳細
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AR antagonist 1 1818885-54-9 Endocrinology/Hormones PROTAC Androgen Receptor Ligand for E3 Ligase Ligands for Target Protein for PROTAC AR antagonist1 Target Protein-binding Moiety AR antagonist-1 Inhibitor LNCaP Linker inhibit cancer Ligands for E3 Ligase VCaP tumor E3 ligase-recruiting Moiety inhibitor