Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 133,000 |
5 mg | 在庫あり | ¥ 291,500 |
25 mg | 在庫あり | ¥ 454,500 |
50 mg | 在庫あり | ¥ 592,500 |
100 mg | 約8-10 週間 | ¥ 780,500 |
説明 | UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction. |
ターゲット&IC50 | PMIX:142 nM, PMX:7 nM |
In vitro |
UCB7362 exhibits significantly higher potency against PMX than PMIX, with an IC50 of 7 nM for the former compared to 142 nM for the latter[1]. Additionally, UCB7362 demonstrates improved selectivity against Cat D and Renin, with an IC50 of 3889 nM and >10,000 nM, respectively[1]. |
In vivo |
UCB7362, when administered orally at doses ranging from 10 to 60 mg/kg twice a day for 4 days, clears parasitemia from peripheral blood[1]. Furthermore, when given intravenously (IV) at 1 mg/kg and orally (PO) at 10 mg/kg in a single administration, UCB7362 exhibits moderate clearance in dogs and cynomolgus monkeys, and moderate to high clearance in rats[1]. |
別名 | GLXC-26743 |
分子量 | 479.96 |
分子式 | C25H26ClN5O3 |
CAS No. | 2610631-17-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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UCB7362 2610631-17-7 Microbiology/Virology Parasite UCB-7362 UCB 7362 GLXC-26743 Inhibitor inhibitor inhibit