The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (IGF-1 and IGF-2), a family of seven high-affinity IGF-binding proteins (IGFBP1 to IGFBP7), as well as associated IGFBP degrading enzymes, referred to collectively as proteases. The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (IGF-1) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer. The IGF axis has been shown to play roles in the promotion of cell proliferation and the inhibition of cell death.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
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TMPJ-01166 | IGFBP-7 Protein, Mouse, Recombinant (His)
IGFBP-7 Protein, Mouse, Recombinant (His)
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Mouse | HEK293 Cells |
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-termina... | |||
TMPJ-01163 | CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)
CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)
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Human | HEK293 Cells |
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN pr... | |||
TMPJ-01162 | CTGF/CCN2 Protein, Human, Recombinant (hFc)
CTGF/CCN2 Protein, Human, Recombinant (hFc)
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Human | HEK293 Cells |
CTGF/CCN2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 67-81 KDa and the accession n... | |||
TMPJ-01161 | CTGF/CCN2 Protein, Human, Recombinant
CTGF/CCN2 Protein, Human, Recombinant
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Human | HEK293 Cells |
CTGF/CCN2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16-25 KDa and the accession number is Q5M8T4. | |||
TMPJ-01082 | IGFBP-5 Protein, Mouse, Recombinant (His)
IGFBP-5 Protein, Mouse, Recombinant (His)
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Mouse | HEK293 Cells |
Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP ... | |||
TMPJ-00811 | IGFBP-1 Protein, Human, Recombinant (His)
IGFBP-1 Protein, Human, Recombinant (His)
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Human | HEK293 Cells |
Insulin-like growth factor-binding protein 1 (IGFBP1) is encoded by 259 amino acid (aa) with 25 aa residue signal peptide that is processed to generate the 234 a... | |||
TMPJ-00345 | IGF2BP-2 Protein, Human, Recombinant (His)
IGF2BP-2 Protein, Human, Recombinant (His)
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Human | E. coli |
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains an... | |||
TMPJ-00164 | IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated
IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | HEK293 Cells |
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. M... |