Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes. Examination of the different signaling cascades induced by RTKs established Ras/MAPK, PI3K, and phospholipase-γ (PLCγ) pathways as key downstream mediators of PDGFR signaling. In addition, reactive oxygen species (ROS)-dependent STAT3 activation has been established to be a key downstream mediator of PDGFR signaling in vascular smooth muscle cells.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPK-00421 | PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi)
PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 Cells |
PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59 kDa an... | |||
TMPK-00420 | PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 Cells |
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. Th... | |||
TMPK-00419 | PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi)
PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 Cells |
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. Th... |