GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated

カタログ番号 TMPK-00197

別名: Placental TGF-β, GDF15, RG-1, MIC-1, PTGFB, PTGF-beta, PDF, PTGF-β, PTGFBPTGF-β, NAG-1, PTGFBPTGF-beta, PLAB, MIC1, GDF-15, Placental TGF-beta

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.88 kDa and the accession number is Q99988.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 214,000
500 μg	約5 days	￥ 854,000
1 mg	約5 days	￥ 1,425,500

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生物学的特性に関する説明

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Product Properties

参考文献

説明

Species	Human
Expression Host	HEK293 Cells
Tag	N-hFc
Accession Number	Q99988
別名	Placental TGF-β, GDF15, RG-1, MIC-1, PTGFB, PTGF-beta, PDF, PTGF-β, PTGFBPTGF-β, NAG-1, PTGFBPTGF-beta, PLAB, MIC1, GDF-15, Placental TGF-beta
Construction	Ala197-Ile308 (H202D)
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	The protein has a predicted MW of 37.88 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Stability & Storage	It is recommended to store the product under sterile conditions at -70℃ or lower. Samples are stable for up to 12 months at -80℃. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.

参考文献

1. Luan HH, et al. GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell. 2019 Aug 22;178(5):1231-1244.e1doi: 10.1016/j.cell.2019.07.033. Epub 2019 Aug 8. PMID: 31402172; PMCID: PMC6863354.

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Keywords

GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated Placental TGF-β GDF15 RG1 NAG 1 RG-1 PTGFBPTGF-b NAG1 PTGF-b MIC-1 PTGFB PTGF-beta RG 1 MIC 1 PDF PTGF-β PTGFBPTGF-β GDF 15 NAG-1 PTGFBPTGF-beta Placental TGF-b PLAB MIC1 GDF-15 Placental TGF-beta recombinant recombinant-proteins proteins protein