ACVR2A Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41.4 kDa and the accession number is A2AI38.
説明 | ACVR2A Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41.4 kDa and the accession number is A2AI38. |
Species | Mouse |
Expression Host | HEK293 Cells |
Tag | His, hFc |
Accession Number | A2AI38 |
別名 | Acvr2, activin A receptor, type IIA, ActrIIa, TactrII |
Construction | The extracellular domain of Mouse ACVR2A (NP_031422.3) (Met 1-Pro 134) was fused with the C-terminal polyhistidine-tagged Fc region of Human IgG1 at the C-terminus. |
Protein Purity | > 97 % as determined by SDS-PAGE |
分子量 | 41.4 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways. |
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Please read the User Guide of Recombinant Proteins for more specific information.
ACVR2A Protein, Mouse, Recombinant (His & hFc) Acvr2 activin A receptor, type IIA ActrIIa TactrII recombinant recombinant-proteins proteins protein