Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,000 | |||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 25,500 | |||
25 mg | 在庫あり | ¥ 47,500 | |||
50 mg | 在庫あり | ¥ 82,000 | |||
100 mg | 在庫あり | ¥ 121,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,000 |
説明 | Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor. |
ターゲット&IC50 | R15B-PP1c holophosphatase:33 nM(Kd) |
In vitro | Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment. |
In vivo | Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease. |
分子量 | 291.13 |
分子式 | C10H12Cl2N4O2 |
CAS No. | 2242616-04-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (137.4 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Raphin1 acetate 2242616-04-0 Metabolism Phosphatase Raphin1 Raphin-1 acetate Raphin-1 Raphin 1 Raphin1 Acetate inhibit Inhibitor inhibitor