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CD155/PVR Protein, Human, Recombinant (His)

カタログ番号 TMPY-01386
別名: NECL5, TAGE4, PVS, CD155, HVED, Necl-5, poliovirus receptor

CD155/PVR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P15151-1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD155/PVR Protein, Human, Recombinant (His)
パッケージサイズ 在庫状況 単価(税別)
100 μg 在庫あり ¥ 56,000
200 μg 約5 days ¥ 99,000
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
生物学的情報 1.Measured by its binding ability in a functional ELISA. Immobilized human CD155 at 2 μg/mL (100 μL/well) can bind human DNAM1 , the EC50 of human DNAM1/CD226 is 50-300 ng/mL. 2.Loaded Human CD226 Protein, hFc Tag on ProA Biosensor, can bind human CD155 protein, His Tag with an affinity constant of 0.87µM as determined in BLI assay (Routinely tested). 3.Loaded Recombinant Human TIGIT Protein, hFc Tag on ProA Biosensor, can bind Recombinant Human CD155/PVR Protein, His Tag with an affinity constant of 0.18 uM as determined in BLI assay (Routinely tested).

説明 CD155/PVR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P15151-1.
Species Human
Expression Host HEK293 Cells
Tag His
Accession Number P15151-1
別名 NECL5, TAGE4, PVS, CD155, HVED, Necl-5, poliovirus receptor
Construction The Human CD155 isoform Alpha (P15151-1) extracellular domain (Met1-Asn343) was fused with a polyhistidine tag at the C-terminus.
Protein Purity ≥ 97 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

分子量 36.5 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

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Keywords

CD155/PVR Protein, Human, Recombinant (His) NECL5 TAGE4 NECL-5 PVS NECL 5 CD155 CD-155 CD 155 TAGE-4 TAGE 4 HVED Necl-5 poliovirus receptor recombinant recombinant-proteins proteins protein