CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His)

カタログ番号 TMPJ-00920

別名: TNFSF5, Tumor necrosis factor ligand superfamily member 5, CD40LG, CD40 Ligand, HIGM1, tumor necrosis factor (ligand) superfamily member 5, T-BAM, T-B cell-activating molecule

CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and a 214 aa extracellular region. CD40 Ligand is expressed as a homotrimer on platelets and activated T cells and B cells. It is upregulated following stimulation of basophils, eosinophils, fibroblasts, mast cells, monocytes, natural killer cells, vascular endothelial cells, and smooth muscle cells. CD40 Ligand binds and activates CD40, which is expressed on the surface of B cells, dendritic cells,macrophages, monocytes, platelets, endothelial cells, and epithelial cells. Monomeric, dimeric, and trimeric forms of soluble CD40 Ligand bind to oligomeric CD40 on cell membranes. CD40 ligation by CD40 Ligand promotes B cell activation and T celldependent humoral responses. CD40 Ligand dysregulation on T cells and antigen presenting cells contributes to the immune deficiency associated with HIV infection and AIDS. It is also implicated in the pathology of multiple cardiovascular diseases including atherosclerosis, atherothrombosis, and restenosis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His)

パッケージサイズ	在庫状況	単価(税別)
10 μg	約5 days	￥ 25,500
50 μg	約5 days	￥ 71,500
500 μg	約5 days	￥ 319,000
1 mg	約5 days	￥ 454,500

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生物学的特性に関する説明

Technical Params

Product Properties

説明

Species	Mouse
Expression Host	HEK293 Cells
Tag	N-6xHis
Accession Number	P27548
別名	TNFSF5, Tumor necrosis factor ligand superfamily member 5, CD40LG, CD40 Ligand, HIGM1, tumor necrosis factor (ligand) superfamily member 5, T-BAM, T-B cell-activating molecule
Amino Acid	Met112-Leu260
Construction	Met112-Leu260
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	20 KDa (reducing condition)

Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 200 mM NaCl, 0.1 mM EDTA, pH 7.0.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and a 214 aa extracellular region. CD40 Ligand is expressed as a homotrimer on platelets and activated T cells and B cells. It is upregulated following stimulation of basophils, eosinophils, fibroblasts, mast cells, monocytes, natural killer cells, vascular endothelial cells, and smooth muscle cells. CD40 Ligand binds and activates CD40, which is expressed on the surface of B cells, dendritic cells,macrophages, monocytes, platelets, endothelial cells, and epithelial cells. Monomeric, dimeric, and trimeric forms of soluble CD40 Ligand bind to oligomeric CD40 on cell membranes. CD40 ligation by CD40 Ligand promotes B cell activation and T celldependent humoral responses. CD40 Ligand dysregulation on T cells and antigen presenting cells contributes to the immune deficiency associated with HIV infection and AIDS. It is also implicated in the pathology of multiple cardiovascular diseases including atherosclerosis, atherothrombosis, and restenosis.

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Keywords

CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His) TNFSF5 Tumor necrosis factor ligand superfamily member 5 CD40LG TNFSF 5 TNFSF-5 CD40 Ligand HIGM1 tumor necrosis factor (ligand) superfamily member 5 HIGM 1 T-BAM T-B cell-activating molecule HIGM-1 recombinant recombinant-proteins proteins protein