EGFR Protein, Human, Recombinant (Isoform Viii, hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is NP_001333870.1.
説明 | EGFR Protein, Human, Recombinant (Isoform Viii, hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is NP_001333870.1. |
Species | Human |
Expression Host | Baculovirus Insect Cells |
Tag | C-hFc |
Accession Number | NP_001333870.1 |
別名 | NISBD2, epidermal growth factor receptor, ERBB, PIG61, mENA, ERBB1, HER1 |
Construction | The Human EGFR (NP_001333870.1) (Met1-Lys375) was expressed with the Fc region of Human IgG1 at the C-terminus. |
Protein Purity | > 95 % as determined by SDS-PAGE. |
分子量 | 65.1 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 100 mM Glycine, 10 mM NaCl, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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Please read the User Guide of Recombinant Proteins for more specific information.
EGFR Protein, Human, Recombinant (Isoform Viii, hFc) HER-1 PIG 61 NISBD2 NISBD-2 epidermal growth factor receptor ERBB PIG-61 NISBD 2 PIG61 mENA HER 1 ERBB1 HER1 ERBB-1 ERBB 1 recombinant recombinant-proteins proteins protein