EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled

The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.6 kDa and the accession number is NP_001333870.1.

EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 321,500
500 μg	約5 days	￥ 854,000
1 mg	約5 days	￥ 1,425,500

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説明

Species	Human
Expression Host	HEK293
Tag	C-His-Avi
Accession Number	NP_001333870.1
別名	LEGFR, ERBB1, EGFR, HER1, PIG61, NISBD2, EC 2.7.10, ERBB, EC 2.7.10.1, mENA
Construction	Recombinant FITC-Labeled Human EGFRVIII Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Leu25-Ser378.[Accession \|NP_001333870.1]
Protein Purity	> 95% as determined by Tris-Bis PAGE
分子量	The protein has a predicted MW of 41.6 kDa. Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Stability & Storage	Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.

参考文献

1. Pedersen M W, et al. The type III epidermal growth factor receptor mutation Biological significance and potential target for anti-cancer therapy[J]. Annals of Oncology, 2001, 12(6):745-760.

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EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled

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