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EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled

カタログ番号 TMPK-00689
別名: EC 2.7.10.1, EC 2.7.10, ERBB1, EGFR, mENA, NISBD2, HER1, ErbB, PIG61, LEGFR

The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.6 kDa and the accession number is NP_001333870.1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
パッケージサイズ 在庫状況 単価(税別)
100 μg 約5 days ¥ 321,500
500 μg 約5 days ¥ 854,000
1 mg 約5 days ¥ 1,425,500
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
説明 The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.6 kDa and the accession number is NP_001333870.1.
Species Human
Expression Host HEK293 Cells
Tag C-His-Avi
Accession Number NP_001333870.1
別名 EC 2.7.10.1, EC 2.7.10, ERBB1, EGFR, mENA, NISBD2, HER1, ErbB, PIG61, LEGFR
Construction Leu25-Ser378
分子量 41.6 kDa (predicted)
Endotoxin < 1 EU/μg by the LAL method.
Formulation Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Stability & Storage

It is recommended to store the product under sterile conditions at -70℃ or lower. Samples are stable for up to 6 months at -80℃. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.

参考文献

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Keywords

EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled EC 2.7.10.1 EC 2.7.10 ERBB1 ERBB-1 EGFR PIG-61 HER 1 mENA HER-1 NISBD2 NISBD-2 HER1 ErbB PIG61 LEGFR PIG 61 NISBD 2 ERBB 1 recombinant recombinant-proteins proteins protein