Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 42,500 |
50 μg | 約5 days | ¥ 125,000 |
500 μg | 約5 days | ¥ 436,000 |
1 mg | 約5 days | ¥ 682,000 |
説明 | Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
Species | Mouse |
Expression Host | HEK293 Cells |
Tag | C-6xHis |
Accession Number | P04187 |
別名 | Gzmb, Cytotoxic cell protease 1, Fragmentin-2, CTLA-1, Granzyme B(G, H), Ctla1, CCP1 |
Amino Acid | Gly19-Ser247 |
Construction | Gly19-Ser247 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 35 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
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Please read the User Guide of Recombinant Proteins for more specific information.
Granzyme B/GZMB Protein, Mouse, Recombinant (His) Gzmb CTLA 1 Cytotoxic cell protease 1 CCP 1 CCP-1 Fragmentin-2 CTLA-1 Granzyme B(G H) Ctla1 CCP1 recombinant recombinant-proteins proteins protein