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HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

カタログ番号 TMPK-01437
別名: FLJ92943, HLA-A, TP53, Antigen NY-CO-13, TRP53, MHC, BCC7, P53, LFS1

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
パッケージサイズ 在庫状況 単価(税別)
100 μg お問い合わせ ¥ 168,500
1 mg お問い合わせ ¥ 1,124,500
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生物学的特性に関する説明
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Product Properties
参考文献
説明 p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
Species Human
Expression Host HEK293 Cells
Tag C-His-Avi
Accession Number A0A140T913(HLA-A*02:01)&P61769(B2M)&HMTEVVRHC
別名 FLJ92943, HLA-A, TP53, Antigen NY-CO-13, TRP53, MHC, BCC7, P53, LFS1
Construction Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRHC peptide. PE-labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin.
Endotoxin < 1 EU/μg by the LAL method.
Formulation Supplied as 0.22 μm filtered solution in 20 mM PB, 500 mM NaCl, 0.2% BSA (pH 8.0).
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.

参考文献

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Keywords

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled FLJ92943 HLA-A TP53 Antigen NY-CO-13 TRP53 MHC BCC7 P53 LFS1 recombinant recombinant-proteins proteins protein