Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.
パッケージサイズ | 在庫状況 | 単価(税別) |
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10 μg | 在庫あり | ¥ 27,000 |
20 μg | 約5 days | ¥ 44,000 |
50 μg | 約5 days | ¥ 80,500 |
100 μg | 約5 days | ¥ 121,000 |
生物学的情報 |
Measured by its ability to block human IL-15-induced proliferation of CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 0.35-3.5 ng/ml. (QC verified)
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説明 | Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-hhFc |
Accession Number | Q13261-3 |
別名 | interleukin-15 receptor subunit α, IL15RA, interleukin-15 receptor subunit alpha, IL-15RA, IL-15R-α, α, MGC104179, CD215 antigen, IL-15 receptor subunit α, CD215, IL-15 receptor subunit alpha, IL-15R-alpha, alpha, interleukin 15 receptor |
Amino Acid | Ile31-Thr172 |
Construction | Ile31-Thr172 |
Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
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分子量 | 60-75 KDa, reducing conditions |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells. |
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Please read the User Guide of Recombinant Proteins for more specific information.
IL-15RA Protein, Human, Recombinant (hFc, Human Cells) interleukin-15 receptor subunit α IL15RA CD-215 interleukin-15 receptor subunit alpha IL-15RA IL-15R-α α MGC104179 CD 215 CD215 antigen IL-15 receptor subunit α CD215 IL-15 receptor subunit alpha MGC 104179 IL-15R-alpha alpha MGC-104179 interleukin 15 receptor recombinant recombinant-proteins proteins protein