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Interleukin

Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells. The human genome encodes more than 50 interleukins and related proteins. The function of the immune system primarily depends on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by CD4 helper T-lymphocyte, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells.
Cat. No. 製品名 CAS No. Purity Chemical Structure
TQ0181 Resatorvid 243984-11-4 98%
Resatorvid (TAK-242) (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM,...
T6207 SC144 895158-95-9 98%
SC144 is an orally active small-molecule gp130 inhibitor.
T4403 AX-024 hydrochloride 1704801-24-0 98%
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TN...
T26326 VU0285655-1 1158347-73-9 98%
VU0285655-1(BML-280) is a potent and selective phospholipase D2 (PLD2) inhibitor that inhibits the proliferation of PLD2-deficient cells.VU0285655-1 has an inhib...
T36526 IL-17 modulator 4 2446803-65-0 98%
IL-17 modulator 4 is a prodrug of IL-17 modulator 1 which is an efficacious modulator of IL-17.
T1813 VGX-1027 6501-72-0 98%
VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
T10497 Benralizumab 1044511-01-4 98%
Benralizumab (MEDI-563) is a monoclonal antibody targeting the interleukin-5 receptor alpha (IL-5Rα). It enhances antibody-dependent cell-mediated cytotoxicity, ...
T0117 Suplatast (Tosilate) 94055-76-2 98%
Suplatast Tosilate (IPD 1151T) is a novel capsular anti-asthmatic drug. It ( IC50 above 100 μM) inhibits both IgE production, IL-4 and IL-5 synthesis.
T76956 Vixarelimab 2243320-83-2 98%
Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody with affinity for the beta chain of the OSM receptor and inhibition of IL-31 and OSM...
T76910 Astegolimab 2173054-79-8 98%
Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of ...
T76891 Oxelumab 1186098-83-8 98%
Oxelumab (R 4930) is a human monoclonal antibody for OX40L. Oxelumab could be used to study asthma.
T76883 Talacotuzumab 1826831-79-1 98%
Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has a high affin...
T76775 Fezakinumab 1007106-86-6 98%
Fezakinumab is a potent monoclonal antibody to interleukin-22 (IL-22). Fezakinumab can be used to study immune system diseases and inflammation-related condition...
T76747 Fletikumab 1357158-22-5 98%
Fletikumab (NNC0109-0012) is a monoclonal antibody against IL-20 that is often used as an IL-20 inhibitor.Fletikumab is used in the study of rheumatoid arthritis...
T76724 Nemolizumab 1476039-58-3 98%
Nemolizumab (CIM331) is a humanized monoclonal antibody against human interleukin-31 receptor A that inhibits the binding and subsequent signal transduction of i...
T73698 Basiliximab 179045-86-4 98%
Basiliximab (CHI 621) is a chimeric mouse/human IgG1 monoclonal recombinant antibody against the interleukin-2 receptor. Basiliximab has good immunosuppressive a...
TN4379 Kansuinine A 57701-86-7 98%
Kansuinine A possesses analgesic props, it also shows NGF inducing activity.
T4450 GIBH-130 1252608-59-5 98%
GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
T9911 Tocilizumab 375823-41-9 98%
Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor
T2061 APY0201 1232221-74-7 98%
APY0201 is a effective, highly specific, ATP-competitive PIKfyve inhibitor (IC50: 5.2 nM). It can interrupt the conversion of phosphatidylinositol 3-phosphate (P...
Resatorvid
TQ0181
Resatorvid (TAK-242) (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM,...
SC144
T6207
SC144 is an orally active small-molecule gp130 inhibitor.
AX-024 hydrochloride
T4403
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TN...
VU0285655-1
T26326
VU0285655-1(BML-280) is a potent and selective phospholipase D2 (PLD2) inhibitor that inhibits the proliferation of PLD2-deficient cells.VU0285655-1 has an inhib...
IL-17 modulator 4
T36526
IL-17 modulator 4 is a prodrug of IL-17 modulator 1 which is an efficacious modulator of IL-17.
VGX-1027
T1813
VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
Benralizumab
T10497
Benralizumab (MEDI-563) is a monoclonal antibody targeting the interleukin-5 receptor alpha (IL-5Rα). It enhances antibody-dependent cell-mediated cytotoxicity, ...
Suplatast (Tosilate)
T0117
Suplatast Tosilate (IPD 1151T) is a novel capsular anti-asthmatic drug. It ( IC50 above 100 μM) inhibits both IgE production, IL-4 and IL-5 synthesis.
Vixarelimab
T76956
Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody with affinity for the beta chain of the OSM receptor and inhibition of IL-31 and OSM...
Astegolimab
T76910
Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of ...
Oxelumab
T76891
Oxelumab (R 4930) is a human monoclonal antibody for OX40L. Oxelumab could be used to study asthma.
Talacotuzumab
T76883
Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has a high affin...
Fezakinumab
T76775
Fezakinumab is a potent monoclonal antibody to interleukin-22 (IL-22). Fezakinumab can be used to study immune system diseases and inflammation-related condition...
Fletikumab
T76747
Fletikumab (NNC0109-0012) is a monoclonal antibody against IL-20 that is often used as an IL-20 inhibitor.Fletikumab is used in the study of rheumatoid arthritis...
Nemolizumab
T76724
Nemolizumab (CIM331) is a humanized monoclonal antibody against human interleukin-31 receptor A that inhibits the binding and subsequent signal transduction of i...
Basiliximab
T73698
Basiliximab (CHI 621) is a chimeric mouse/human IgG1 monoclonal recombinant antibody against the interleukin-2 receptor. Basiliximab has good immunosuppressive a...
Kansuinine A
TN4379
Kansuinine A possesses analgesic props, it also shows NGF inducing activity.
GIBH-130
T4450
GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
Tocilizumab
T9911
Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor
APY0201
T2061
APY0201 is a effective, highly specific, ATP-competitive PIKfyve inhibitor (IC50: 5.2 nM). It can interrupt the conversion of phosphatidylinositol 3-phosphate (P...
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