Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs.
パッケージサイズ | 在庫状況 | 単価(税別) |
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10 μg | 在庫あり | ¥ 19,000 |
50 μg | 約5 days | ¥ 57,500 |
500 μg | 約5 days | ¥ 280,000 |
1 mg | 約5 days | ¥ 626,500 |
生物学的情報 |
Immobilized Mouse IL-33 at 5μg/ml (100 μl/well) can bind Mouse ST2-Fc. The ED50 of Mouse ST2-Fc is 0.33 ug/ml. (Regularly tested)
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説明 | Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs. |
Species | Mouse |
Expression Host | E. coli |
Tag | Tag Free |
Accession Number | Q8BVZ5 |
別名 | Interleukin-1 family member 11, NF-HEV and IL- 1F11, NKHEV, IL-33, Interleukin 33, DVS27, IL33, C9orf26 |
Amino Acid | Ser109-Ile266 |
Construction | Ser109-Ile266 |
Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
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分子量 | 18 KDa, reducing conditions |
Endotoxin | < 0.001 ng/µg (0.01 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 1 mM DTT, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs. |
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Please read the User Guide of Recombinant Proteins for more specific information.
IL-33 Protein, Mouse, Recombinant Interleukin-1 family member 11 NF-HEV and IL- 1F11 IL 33 NKHEV IL-33 DVS 27 Interleukin 33 DVS27 IL33 DVS-27 C9orf26 recombinant recombinant-proteins proteins protein