LOX-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P78380.
説明 | LOX-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P78380. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | His |
Accession Number | P78380 |
別名 | LOXIN, SCARE1, SLOX1, LOX1, OLR1, oxidized low density lipoprotein (lectin-like) receptor 1, CLEC8A |
Construction | The Human OLR1 (P78380) extracellular domain (Ser 61-Gln 273) was expressed, with a polyhistidine tag at the N-terminus. |
Protein Purity | ≥ 85 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC. |
分子量 | 26.5 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is induced by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes, and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions. |
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Please read the User Guide of Recombinant Proteins for more specific information.
LOX-1 Protein, Human, Recombinant (His) SLOX 1 SCARE-1 LOXIN SCARE1 SLOX1 OLR 1 OLR-1 LOX 1 LOX1 SLOX-1 OLR1 SCARE 1 oxidized low density lipoprotein (lectin-like) receptor 1 LOX-1 CLEC8A recombinant recombinant-proteins proteins protein