PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.

PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

パッケージサイズ	在庫状況	単価(税別)
50 μg	約5 days	￥ 138,000
500 μg	約5 days	￥ 897,500

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説明

Species	Human
Expression Host	Baculovirus Insect Cells
Tag	His, GST
Accession Number	P18433-2
別名	LRP, PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST), HPTPA, R-PTP-α, HEPTP, protein tyrosine phosphatase, receptor type, A, HPTPalpha, HPTPα, RPTPA, PTPRL2, HLPR, PTPA, R-PTP-alpha
Construction	The Human PTPRA isoform 2 (P18433-2) cytoplasmic domain (Ala 174-Lys 793) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Protein Purity	> 90 % as determined by SDS-PAGE
分子量	99 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 20% gly, 3 mM DTT.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.

参考文献

1. Kaplan R, et al. (1990) Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc Natl Acad Sci U S A. 87 (18): 7000-4. 2. Hertog JD, et al. (1996) Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains. EMBO J. 15 (12): 3016-27. 3. Ye H, et al. (2011) Receptor-like protein-tyrosine phosphatase a enhances cell surface expression of neural adhesion molecule NB-3. J Biol Chem. 286 (29): 26071-80.

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PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

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