| T35384 |
TPX-0046
|
2359650-19-2
|
98%
|
|
|
TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.
|
| T13186 |
TL02-59
|
1315330-17-6
|
98%
|
|
|
TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-5...
|
| T13000 |
Src Inhibitor 3
|
2380027-49-4
|
98%
|
|
|
Src Inhibitor 3 is an effective inhibitor of c-terminal Src kinase (IC50 <3 nM in CSK HTRF, <4 nM in Caliper assay). Src Inhibitor 3 increases T cell proliferati...
|
| T10531 |
BGB-102
|
807640-87-5
|
98%
|
|
|
BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular deg...
|
| T9723 |
GluR6 antagonist-1
|
323176-64-3
|
98%
|
|
|
GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.
|
| T75163 |
GW297361
|
388627-21-2
|
98%
|
|
|
GW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1 ...
|
| T8544 |
Masitinib mesylate
|
1048007-93-7
|
98%
|
|
|
Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα...
|
| T13156L |
TG 100572 Hydrochloride
|
867331-64-4
|
98%
|
|
|
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
|
| T8499 |
ECF506
|
1914078-41-3
|
|
|
|
eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)
|
| T14072 |
A-443654
|
552325-16-3
|
|
|
|
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
| T1811 |
WH-4-023
|
837422-57-8
|
|
|
|
WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.
|
| T3593 |
Src Inhibitor 1
|
179248-59-0
|
100%
|
|
|
Src Inhibitor 1 (Src Kinase Inhibitor 1) is a potent and selective dual site Src tyrosine kinase inhibitor.
|
| T13157 |
TG 100801
|
867331-82-6
|
100%
|
|
|
TG 100801 is a dual inhibitor of VEGFr2 and Src family (Src and YES) kinases and is a candidate compound for the treatment of age-related macular degeneration (A...
|
| T2372L |
Ponatinib Hydrochloride
|
1114544-31-8
|
100%
|
|
|
Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.3...
|
| T6896 |
Tolimidone
|
41964-07-2
|
100%
|
|
|
Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.
|
| T68455 |
AP23846
|
878654-51-4
|
100%
|
|
|
AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream a...
|
| T6266 |
PP2
|
172889-27-9
|
95.65%
|
|
|
PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.
|
| T8976 |
PD-089828
|
179343-17-0
|
96.78%
|
|
|
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitiv...
|
| T6997 |
SU6656
|
330161-87-0
|
97%
|
|
|
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
|
| T2608 |
CHIR-98014
|
252935-94-7
|
97.09%
|
|
|
CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
|
