Serpin A1 Protein, Human, Recombinant (aa 25-418, His)

カタログ番号 TMPJ-00505

別名: Alpha-1-Antiproteinase, α-1-Antiproteinase, SERPINA1, Serpin A1, AAT, Alpha-1 Protease Inhibitor, Alpha-1-Antitrypsin, PI, α-1-Antitrypsin, α-1 Protease Inhibitor

Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency, and consequently lead to several clinical complications such as pulmonary emphysema, juvenile hepatitis, cirrhosis, and hepatocellular carcinoma. For example, the Z variants (Glu342 to Lys) forms intracellular inclusion bodies, is not secreted, and leads to a severe SerpinA1 deficiency. Accordingly, Serpin A1 deficiency in circulation is associated with emphysema or liver disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Serpin A1 Protein, Human, Recombinant (aa 25-418, His)

パッケージサイズ	在庫状況	単価(税別)
10 μg	約5 days	￥ 42,500
50 μg	約5 days	￥ 125,000
500 μg	約5 days	￥ 436,000
1 mg	約5 days	￥ 626,500

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DATASHEET SDS

生物学的特性に関する説明

Technical Params

Product Properties

説明

Species	Human
Expression Host	HEK293 Cells
Tag	C-6xHis
Accession Number	AAH11991.1
別名	Alpha-1-Antiproteinase, α-1-Antiproteinase, SERPINA1, Serpin A1, AAT, Alpha-1 Protease Inhibitor, Alpha-1-Antitrypsin, PI, α-1-Antitrypsin, α-1 Protease Inhibitor
Amino Acid	Glu25-Lys418
Construction	Glu25-Lys418
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	50-65 KDa (reducing condition)

Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, 2 mM CaCl<sub>2</sub>, pH 7.5.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency, and consequently lead to several clinical complications such as pulmonary emphysema, juvenile hepatitis, cirrhosis, and hepatocellular carcinoma. For example, the Z variants (Glu342 to Lys) forms intracellular inclusion bodies, is not secreted, and leads to a severe SerpinA1 deficiency. Accordingly, Serpin A1 deficiency in circulation is associated with emphysema or liver disease.

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Keywords

Serpin A1 Protein, Human, Recombinant (aa 25-418, His) Alpha-1-Antiproteinase α-1-Antiproteinase SERPINA 1 a-1 Protease Inhibitor SERPINA1 Serpin A1 AAT Alpha-1 Protease Inhibitor Alpha-1-Antitrypsin PI α-1-Antitrypsin a-1-Antiproteinase SERPINA-1 a-1-Antitrypsin α-1 Protease Inhibitor recombinant recombinant-proteins proteins protein