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T80051 |
Amidase
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Endogenous Metabolite
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Amidases, belonging to the nitrilase superfamily, catalyze amide hydrolysis to yield carboxylic acid and ammonia. These enzymes feature a conserved AS sequence of about 130 amino acids and are pivotal in essential metabo... |
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T78361 |
Penicillin amidase
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Penicillin acylase |
Others
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Penicillin amidase (Penicillin acylase) is an enzyme utilized for cleaving the acyl side chains from penicillins. It facilitates the production of 6-aminopenicillanic acid and is also employed in resolving racemic mixtur... |
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T40051 |
Acid Ceramidase-IN-1
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Others
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Acid Ceramidase-IN-1 is an orally available and brain-permeable acid ceramidase (AC, ASAH-1) inhibitor.Acid Ceramidase-IN-1 can be used in the study of neurological disorders. |
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T75142 |
Acid Ceramidase-IN-2
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Others
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Acid Ceramidase-IN-2 (compound 1), an acid ceramidase inhibitor, exhibits potentially antiproliferative and cytostatic effects. This compound is of interest due to the overexpression of human acid ceramidase in prostate ... |
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T75407 |
Endoglycoceramidase I (EGCase I)
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Others
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Endoglycoceramidase I (EGCase I), a glycosidase frequently utilized in biochemical studies, catalyzes a transglycosylation reaction. This process involves transferring the sugar moiety of GSLs to the primary hydroxyl gro... |
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T75406 |
Endoglycoceramidase II (EGCase II)
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Others
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Endoglycoceramidase II (EGCase II), an endo-β-glucosidase, catalyzes the hydrolysis of the β-glycosidic linkage between oligosaccharides and ceramides in glycosphingolipids, releasing the complete glycan from ceramide [1... |
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T68492 |
AM 374
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HDSF,Hexadecanesulfonyl fluoride |
FAAH
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AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease resear... |
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T41032 |
Lysostaphin
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Antibacterial
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Lysostaphin is a potent antistaphylococcal compound that exhibits enzymatic activity through three distinct enzymes: glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase, and N-acetyl muramyl-L-alanine amidase. |
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T15948 |
MAFP
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Methyl Arachidonyl Fluorophosphonate |
Phospholipase
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MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2. |
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T9528 |
ARN19702
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Others
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ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC 50 of 230 nM for human NAAA. ARN19702 exhibits a broad analgesic profile [1] [2]. |
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T77513 |
2-Chlorophenylboronic acid
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FAAH
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2-Chlorophenylboronic acid is a monohalogenated phenylboronic acid, which is an important pharmaceutical intermediate and is widely used in the synthesis of new drugs.2-Chlorophenylboronic acid has an inhibitory effect o... |
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T10370 |
ARN 077
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URB913 |
Others
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ARN 077 is a selective N-acylethanolamine acid amidase (NAAA) inhibitor (IC50: 7 nM for human NAAA). ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS. |
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T30137 |
ARN14686
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Others
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ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry. |
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T60456 |
ARN726
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Others
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ARN726 is a potent inhibitor of NAAA (N-acylethanolamine acid amidase) with an IC 50 of 0.073 μM which decreases the motivation for alcohol in a dose-dependent manner [1] [2]. |
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T76145 |
Clostripain
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Others
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Clostripain (Clostridiopeptidase B), a proteolytic enzyme derived from Clostridium histolyticum, exhibits esterase, amidase, and protease activities. It is notably specific for cleaving carboxy-terminal arginine residues... |
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T75412 |
Peptide-N-Glycosidase F (PNGaseF)
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Others
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Peptide-N-Glycosidase F (PNGase F), an asparagine amidase, catalyzes the detachment of N-linked oligosaccharides from the innermost GlcNAc to asparagine residues within high mannose, hybrid, and complex oligosaccharides ... |
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T84653 |
17-phenyl trinor Prostaglandin F2α diethyl amide
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Bimatoprost diethyl amide |
Others
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17-Phenyl trinor Prostaglandin F2αdiethyl amide (17-phenyl trinor PGF2αdiethyl amide) is a Prostaglandin F2α(PGF2α) analog characterized by the substitution of the C-1 carboxyl group with an N-diethyl amide. Prostaglandi... |
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T60767 |
NAAA-IN-1
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Others
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NAAA-IN-1 (Compound 1) can be used in the inflammation and pain research. NAAA-IN-1 is a potent and selective NAAA inhibitor (IC 50 = 7 nM). NAAA is a cysteine amidase. NAAA preferentially hydrolyzes the endogenous bioli... |
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T60378 |
NAAA-IN-2
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Others
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NAAA-IN-2 (Compound 9), a potent and selective inhibitor of NAAA, exhibits an IC50 of 50 nM. NAAA, a cysteine amidase, primarily breaks down the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OE... |
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T37930 |
15(R)-17-phenyl trinor Prostaglandin F2α
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15(R)-17-phenyl trinor Prostaglandin F2α |
Others
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17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl tr... |
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T60432 |
NAAA-IN-3
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Others
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NAAA-IN-3 (Compound 17a) is a potent and selective NAAA inhibitor with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanola... |
