|
T7545 |
6-Aminonicotinamide
|
|
Others
|
|
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme. |
|
T4047 |
Bisantrene
|
CL216942 |
Topoisomerase
|
|
Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and ... |
|
T39757 |
EC2629
|
EC2629 |
Others
|
|
EC2629 is a highly potent folate- receptor-targeted DNA crosslinking agent. |
|
T24453 |
Metamelfalan
|
NSC-67781,Metamelfalanum,NSC67781,NSC 67781,m-L-Sarcolysin |
Others
|
|
Metamelfalan is an alkylating nitrogen mustard with potential antineoplastic activity. It causes crosslinking of DNA, thereby preventing DNA replication and eventually cellular proliferation. |
|
T19193 |
Amotosalen hydrochloride
|
S-59 |
Others
|
|
Amotosalen hydrochloride (S-59) is a light-activated, RNA-, DNA-crosslinking psoralen compound and is used to neutralize pathogens. |
|
T29964 |
Ametantrone Acetate
|
CI-881 |
Others
|
|
Ametantrone Acetate is a topoisomerase II inhibitor of anthrapyrazole family, which can lead to DNA covalent crosslinking. |
|
T19560 |
SGD-1882
|
PBD dimer |
Others
|
|
SGD-1882 is a agent of cytotoxic, DNA minor-groove crosslinking pyrrolobenzodiazepine (PBD) dimer, and acting as the payload for ADCs. |
|
T61870 |
(rel)-Oxaliplatin
|
|
Others
|
|
(rel)-Oxaliplatin is a DNA synthesis inhibitor that induces DNA crosslinking damage, inhibits DNA replication and transcription, and stimulates apoptosis. This compound has applications in cancer research [1] [2] [3]. |
|
T70229 |
Laromustine
|
|
Others
|
|
Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanin... |
|
T16025 |
SGD-1910
|
MC-Val-Ala-PBD |
Others
|
|
MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1]. |
|
T36745 |
CDPCP
|
|
Others
|
|
cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting pr... |
