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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T6467 Cardioxane 149003-01-0 98%
Cardioxane (ADR-529) is a cardio-protective drug.
TQ0134 Podocarpusflavone A 22136-74-9 98%
Podocarpusflavone A is a DNA topoisomerase I and STAT3 inhibitor, a flavonoid chemically inactive isolated from the endemic Taiwanese plant, Luo Han Guo, with po...
T15578 Indotecan 915303-09-2 98%
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
T2830 Betulinic acid 472-15-1
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
T15507 Hycanthone 3105-97-3
Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II...
T1451 Levofloxacin hydrate 138199-71-0
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacter...
T0425L Pefloxacin Mesylate Dihydrate 149676-40-4
Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
T8747 Levofloxacin hydrochloride 177325-13-2
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
T3181 SW044248 522650-83-5
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
T3S1957 9-amino-CPT 91421-43-1
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
T7309 TAS-103 dihydrochloride 174634-09-4
TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.
T1620 Pazufloxacin Mesylate 163680-77-1
Pazufloxacin Mesylate (T-3762) is a fluoroquinolone antibiotic.
T36968 ARN-21934 2230854-93-8 100%
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation wit...
T11090L1 Aldoxorubicin hydrochloride 1361563-03-2 100%
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin ...
T25688 Leurubicin 70774-25-3 100%
Leurubicin (N-Leucyldoxorubicin) is a potential Top II inhibitor for the study of bacterial infections .
T0425 Pefloxacin Mesylate 70458-95-6 100%
Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positiv...
T8333 Aurintricarboxylic acid 4431-00-9 95%
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by ...
T3339 Sophoridine 6882-68-4 96.35%
Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivat...
T15168 DRF-1042 200619-13-2 97.00%
DRF-1042 is an orally active camptothecin analog with antitumor activity and inhibits DNA topoisomerase I. It is used in the study of refractory tumors.
T21319L Gimatecan HCl 97.04%
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
Cardioxane
T6467
Cardioxane (ADR-529) is a cardio-protective drug.
Podocarpusflavone A
TQ0134
Podocarpusflavone A is a DNA topoisomerase I and STAT3 inhibitor, a flavonoid chemically inactive isolated from the endemic Taiwanese plant, Luo Han Guo, with po...
Indotecan
T15578
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
Betulinic acid
T2830
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
Hycanthone
T15507
Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II...
Levofloxacin hydrate
T1451
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacter...
Pefloxacin Mesylate Dihydrate
T0425L
Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
Levofloxacin hydrochloride
T8747
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
SW044248
T3181
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
9-amino-CPT
T3S1957
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
TAS-103 dihydrochloride
T7309
TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.
Pazufloxacin Mesylate
T1620
Pazufloxacin Mesylate (T-3762) is a fluoroquinolone antibiotic.
ARN-21934
T36968
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation wit...
Aldoxorubicin hydrochloride
T11090L1
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin ...
Leurubicin
T25688
Leurubicin (N-Leucyldoxorubicin) is a potential Top II inhibitor for the study of bacterial infections .
Pefloxacin Mesylate
T0425
Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positiv...
Aurintricarboxylic acid
T8333
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by ...
Sophoridine
T3339
Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivat...
DRF-1042
T15168
DRF-1042 is an orally active camptothecin analog with antitumor activity and inhibits DNA topoisomerase I. It is used in the study of refractory tumors.
Gimatecan HCl
T21319L
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
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