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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T6010 Idarubicin hydrochloride 57852-57-0 98%
Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).
T6467 Cardioxane 149003-01-0 98%
Cardioxane (ADR-529) is a cardio-protective drug.
T1293 Gatifloxacin 112811-59-3 98%
Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DN...
T1123 Camptothecin 7689-03-4 98%
(S)-(+)-Camptothecin (NSC-100880) is a specific inhibitor of DNA topoisomerase I (Topo I), isolated from Camptotheca acuminata.
T4047 Bisantrene 78186-34-2 98%
Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting ...
T15507 Hycanthone 3105-97-3 98%
Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II...
T5820 Amsacrine hydrochloride 54301-15-4 98%
Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.
T1451 Levofloxacin hydrate 138199-71-0 98%
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacter...
T1492 Gemifloxacin mesylate 210353-53-0 98%
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial...
T31011 Coralyne chloride 38989-38-7 98%
Coralyne Chloride is a molecular rectifier based on fluorescent DNA, which is constructed into DNA double-stranded bodies by site-specific insertion.
T77584 Tubulin inhibitor 35 2247047-77-2 98%
Tubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migra...
T1444 Lomefloxacin 98079-51-7 98%
Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
T1095 Sparfloxacin 110871-86-8 98%
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
T0425L Pefloxacin Mesylate Dihydrate 149676-40-4 98%
Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
T11249L Dxd 1599440-33-1 98%
Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.
T0274 Cinoxacin 28657-80-9 98%
Cinoxacin (Compound 64716), an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and na...
T3181 SW044248 522650-83-5 98%
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
T3S1957 9-amino-CPT 91421-43-1 98%
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
T1121 Podofilox 518-28-5 98%
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken int...
T6588 Mitoxantrone 65271-80-9 98%
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting ...
Idarubicin hydrochloride
T6010
Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).
Cardioxane
T6467
Cardioxane (ADR-529) is a cardio-protective drug.
Gatifloxacin
T1293
Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DN...
Camptothecin
T1123
(S)-(+)-Camptothecin (NSC-100880) is a specific inhibitor of DNA topoisomerase I (Topo I), isolated from Camptotheca acuminata.
Bisantrene
T4047
Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting ...
Hycanthone
T15507
Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II...
Amsacrine hydrochloride
T5820
Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.
Levofloxacin hydrate
T1451
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacter...
Gemifloxacin mesylate
T1492
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial...
Coralyne chloride
T31011
Coralyne Chloride is a molecular rectifier based on fluorescent DNA, which is constructed into DNA double-stranded bodies by site-specific insertion.
Tubulin inhibitor 35
T77584
Tubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migra...
Lomefloxacin
T1444
Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
Sparfloxacin
T1095
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
Pefloxacin Mesylate Dihydrate
T0425L
Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
Dxd
T11249L
Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.
Cinoxacin
T0274
Cinoxacin (Compound 64716), an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and na...
SW044248
T3181
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
9-amino-CPT
T3S1957
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
Podofilox
T1121
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken int...
Mitoxantrone
T6588
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting ...
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