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T12553 |
PROTAC EED degrader-1
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Others
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PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17. |
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T12554 |
PROTAC EED degrader-2
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Others
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PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11. |
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T3458 |
EED226
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Histone Methyltransferase
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EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM. |
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T61825 |
EED ligand 1
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EED ligand 1 is a highly versatile, potent, and effective inhibitor that specifically targets the EED subunit of the polycomb repressive complex 2 (PRC2) methyltransferase. |
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T17649 |
Boc-GABA-OH
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Others
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PROTAC Linker
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Boc-GABA-OH serves as a PROTAC linker essential for synthesizing UNC6852, an EED-targeted PROTAC[1]. |
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T13954 |
UNC6852
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Histone Methyltransferase
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Ligands for Target Protein for PROTAC
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UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC. |
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T9681 |
MAK-683 hydrochloride
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Histone Methyltransferase
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MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50s of 59, 26, 89 nM in EED Alphascreen binding, ELISA and LC-MS assay. |
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T17931 |
EED226-COOH
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Others
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EED226-COOH, derived from EED226, serves as a ligand targeting the EED protein for PROTAC applications. It attaches to a VHL ligand through a linker, culminating in the formation of UNC6852, which specifically degrades P... |
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T22322 |
EEDi-5285
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UM-EEDi-5285,EEDI5285 |
Histone Methyltransferase
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EEDi-5285, an orally active and highly potent inhibitor targeting embryonic ectoderm development (EED) protein, exhibits anti-cancer activity. It demonstrates exceptional efficacy with an IC50 value of 0.2 nM, indicating... |
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T40223 |
EEDi-5273
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EEDi-5273 is a highly potent and orally efficacious inhibitor of EED, with an approximate IC50 value of 0.2 nM. This compound exhibits exceptional activity, capable of achieving complete and persistent regression of tumo... |
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T124238 |
Rheediaxanthone A
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Rheediaxanthone A is a useful organic compound for research related to life sciences and the catalog number is T124238. |
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T71923 |
EEDQ
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EEDQ is an irreversible dopamine-receptor antagonist.EEDQ is also a highly specific reagent for carboxyl groups. It enables the coupling of acylamino acids with amino acid esters in high yield and without racemization. |
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T76665 |
Z-LEED-FMK
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Z-LEED-FMK is a chemical compound that acts as an inhibitor for caspase-13 and caspase-4. Additionally, it impedes caspase-1 processing in S. typhimurium-infected macrophages [1] [2]. |
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T15201 |
MAK683
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Histone Methyltransferase
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MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay). |
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T10205 |
A-395
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Histone Methyltransferase
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A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC50: 18 nM). |
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T13765 |
MAK683-CH2CH2COOH
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Others
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MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design EED-Targeted PROTAC which are EED degrader-1 and PROTAC EED... |
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T18673 |
(S,R,S)-AHPC-O-Ph-PEG1-NH2
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VH032-O-Ph-PEG1-NH2 |
Others
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(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) serves as an E3 ligase ligand-linker conjugate, integrating a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is utilized in PROTAC EED degrader-... |
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T73945 |
MAK683-CH2CH2COOH hydrochloride
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MAK683-CH2CH2COOH, targeting embryonic ectoderm development protein (EED), alongside a VHL ligand for E3 ubiquitin ligase, contributes to the formulation of PROTAC EED degrader-1 and PROTAC EED degrader-2 [1]. |
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T17660 |
Boc-NH-PEG1-Ph-O-CH2COOH
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Others
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Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC Linker which is used for the EED-targeted PROTAC[1]. |
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T17653 |
Boc-NH-C4-acid
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Others
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PROTAC Linker
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Boc-NH-C4-acid is a PROTAC linker belonging to the Alkyl/ether class, which can be used for the synthesis of PROTAC1 and can degrade EED, EZH2, and SUZ12 in PRC2. |
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T61975 |
Pociredir
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Pociredir (FTX-6058) is a potent, selective and orally active inhibitor of embryonic ectoderm development (EED) (KD= 0.163 nM). Pociredir (FTX-6058) has research value in inflammatory or hemoglobinopathies, such as sickl... |
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T40154 |
FTX-6058
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FTX-6058 is a potent orally active inhibitor targeting Embryonic Ectoderm Development (EED). It effectively induces HbF protein expression in both cell and murine models. This compound holds significant potential for res... |
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T40155 |
FTX-6058 hydrochloride
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FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED), with the ability to induce HbF protein expression in both cell and murine models. This compound is particularly valu... |
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T18672 |
(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc
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VH032-O-Ph-PEG1-NH-Boc |
Others
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(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is an E3 ligase ligand-linker conjugate, specifically designed for targeting the EED protein in PROTAC applications[1]. |
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T18665 |
(S,R,S)-AHPC-C4-NH2 dihydrochloride
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VH032-C4-NH2 dihydrochloride |
Others
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(S,R,S)-AHPC-C4-NH2 dihydrochloride is a chemically derived E3 ligase ligand-linker conjugate, consisting of the (S,R,S)-AHPC VHL ligand and a linker specifically designed for EED-Targeted PROTAC[1]. |
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T18666 |
(S,R,S)-AHPC-C4-NH2
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VH032-C4-NH2 |
Others
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(S,R,S)-AHPC-C4-NH2 is a custom-synthesized conjugate of an E3 ligase ligand-linker, which combines the VHL ligand based on (S,R,S)-AHPC and a linker specifically designed for EED-Targeted PROTAC[1]. |
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T18664 |
(S,R,S)-AHPC-C3-NH2
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VH032-C3-NH2 |
Others
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(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized conjugate consisting of an E3 ligase ligand-linker and the VH032 based VHL ligand, which is commonly used in PROTAC technology. This compound serves as a key component ... |
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T18663 |
(S,R,S)-AHPC-C3-NH2 TFA (2361119-88-0 free base)
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(S,R,S)-AHPC-C3-NH2 TFA,VH032-C3-NH2 TFA |
Others
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(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the sy... |
