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Search Results for " Heparan "

ターゲット

6

阻害剤

2

天然化合物

25

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T16380 OGT 2115 Others
OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 µM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). OGT 2115 also showed antiangiogenic properties (IC50=1 μM).
T69224 Hemisurfen
Hemisurfen is a small molecule, surfen derivative with heparan sulfate antagonist properties.
T36111 L-Iduronic acid sodium salt
L-Iduronic acid sodium salt is a monosaccharide that is an important component of glycosaminoglycans (GAGs) such as heparin, heparan sulfate, and dermatan sulfate.
TP1555 Fibronectin Active Fragment Control
Fibronectin is a high-molecular weight (~440kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins.In addition to integrins, fibronectin also binds extracellular matrix ...
T81940 Lepunafusp alfa JR-171
Lepunafusp alfa (JR-171) is a blood-brain barrier-penetrating fusion protein comprising J-Brain Cargo and α-L-iduronidase (IDUA), a lysosomal enzyme. This compound effectively lowers the levels of heparan sulfate (HS) an...
T81573 Pabinafusp alfa JR-141
Pabinafusp alfa (JR-141), a transferrin receptor-targeting antibody fusing Iduronate 2-sulfatase with an anti-human transferrin receptor antibody, penetrates the blood-brain barrier and inhibits heparan sulfate (HS) accu...
カタログ番号 製品名 別名 ターゲット
T19355 Heparan Sulfate FGFR , Wnt/beta-catenin , Endogenous Metabolite
Heparan Sulfate, a complex and linear polysaccharide, forms a component of glycoproteins called heparan sulfate proteoglycans, abundantly expressed on the cell surface and within the extracellular matrix.
T4825 D-(+)-Xylose D(+)-Xylose,(+)-Xylose,Wood sugar Endogenous Metabolite
D-(+)-Xylose (Wood sugar) is an aldopentose - a monosaccharide containing five carbon atoms and an aldehyde functional group. It has chemical formula C5H10O5 and is 40% as sweet as sucrose. Xylose is also found in mucopo...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-00290 HS3ST1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
HS3ST1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 36 kDa and the accession number is AAH57803.1.
TMPJ-00561 SDC2 Protein, Human, Recombinant (His) Human HEK293 Cells
Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans ...
TMPY-02907 FGF-19 Protein, Human, Recombinant Human E. coli
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inclu...
TMPJ-00137 APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His) Human HEK293 Cells
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to relea...
TMPJ-00865 VEGF121 Protein, Human, Recombinant (His) Human HEK293 Cells
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PD...
TMPY-00828 Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His) Human HEK293 Cells
Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfat...
TMPJ-00375 HGF Protein, Human, Recombinant (His) Human HEK293 Cells
HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propepti...
TMPJ-00863 GNS Protein, Human, Recombinant (His) Human HEK293 Cells
N-Acetylglucosamine-6-Sulfatase is a member of the Sulfatase family. N-Acetylglucosamine-6-Sulfatase is required for the lysosomal degradation of the Glycosaminoglycans (GAG) Heparan Sulfate and Keratan Sulfate. N-Acetyl...
TMPH-02878 PTPRS Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects...
TMPH-02293 UGDH Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role i...
TMPH-03658 Vaccinia virus (strain Copenhagen) Ag35 Protein (His & Myc) VACV E. coli
Envelope protein that binds to heparan sulfate on the cell surface and might provide virion attachment to target cell. Vaccinia virus (strain Copenhagen) Ag35 Protein (His & Myc) is expressed in E. coli expression system...
TMPH-01221 GLCE Protein, Human, Recombinant (His) Human E. coli
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine t...
TMPK-01310 Syndecan-1 Protein, Rabbit, Recombinant (His) Rabbit HEK293 Cells
CD138 (syndecan-1, Sdc-1) is a member of the syndecan family that comprises heparan sulfate proteoglycans. CD138 is significant for cell-cell and cell-matrix interactions.CD138 plays a crucial role in carcinogenesis and ...
TMPH-01447 Human herpesvirus 2 (HHV-2) (strain HG52) Envelope glycoprotein C (His) HHV-2 E. coli
Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Plays also a role in host immune evasion by inhibiting the host complement cascade activation. Human her...
TMPH-01671 Human metapneumovirus (strain CAN97-83) Fusion glycoprotein F0 (His & SUMO) HMPV E. coli
Inactive precursor that is cleaved to give rise to the mature F1 and F2 fusion glycoproteins.; Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native st...
TMPJ-01368 GPC1 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Glypican-1 is a cell membrane protein and belongs to the glypican family. The protein may act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfa...
TMPJ-00128 SLAMF2 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic prog...
TMPH-01080 Ceruloplasmin Protein, Human, Recombinant (His & Myc) Human E. coli
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the ...
TMPJ-01433 Fibronectin Protein, Human, Recombinant (ED-B domain, Avi & His), Biotinylated Human E. coli
Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins, fibronectin binds extracellular matrix components ...
TMPJ-01317 EXTL2 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Exostosin-like 2 (EXTL2) is a member of the exostosin (EXT)-related family which contains five members: EXT1, EXT2, EXTL1, EXTL2, and EXTL3. Studies have shown that EXT gene family members have the activities of heparan ...
TMPY-03405 SPOCK1 Protein, Human, Recombinant (aa 21-429, His) Human Baculovirus Insect Cells
Osteonectin, also known as SPOCK1, is an extracellular heparan/chondroitin sulfate proteoglycan. Members of this family are known as testicans, also called SPOCKs. They are characterized structurally by an N-terminal tes...
TMPJ-01166 IGFBP-7 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase ...
TMPY-01412 Glypican 5 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Glypican-5 (GPC5), is a cell membrane protein that belongs to the glypican family. The glypicans compose a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans that may play a role in the control...
TMPJ-00330 GPC1 Protein, Human, Recombinant (His) Human HEK293 Cells
The Glypicans are a small multigene family of GPI-linked proteoglycans that play a key role in growth factor signaling. Human Glypican 1 (GPC1) is synthesized as a 558 amino acid (aa) preproprecursor that contains a 23 a...
TMPY-05250 CLEC3A Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Elevated CLEC3A expression may correlate with breast IDC metastatic potential and indicate...
HS3ST1 Protein, Human, Recombinant (His)
TMPY-00290
Species: Human
Expression System: Baculovirus Insect Cells
SDC2 Protein, Human, Recombinant (His)
TMPJ-00561
Species: Human
Expression System: HEK293 Cells
FGF-19 Protein, Human, Recombinant
TMPY-02907
Species: Human
Expression System: E. coli
APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)
TMPJ-00137
Species: Human
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His)
TMPJ-00865
Species: Human
Expression System: HEK293 Cells
Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)
TMPY-00828
Species: Human
Expression System: HEK293 Cells
HGF Protein, Human, Recombinant (His)
TMPJ-00375
Species: Human
Expression System: HEK293 Cells
GNS Protein, Human, Recombinant (His)
TMPJ-00863
Species: Human
Expression System: HEK293 Cells
PTPRS Protein, Mouse, Recombinant (His & Myc)
TMPH-02878
Species: Mouse
Expression System: E. coli
UGDH Protein, Human, Recombinant (His & SUMO)
TMPH-02293
Species: Human
Expression System: E. coli
Vaccinia virus (strain Copenhagen) Ag35 Protein (His & Myc)
TMPH-03658
Species: VACV
Expression System: E. coli
GLCE Protein, Human, Recombinant (His)
TMPH-01221
Species: Human
Expression System: E. coli
Syndecan-1 Protein, Rabbit, Recombinant (His)
TMPK-01310
Species: Rabbit
Expression System: HEK293 Cells
Human herpesvirus 2 (HHV-2) (strain HG52) Envelope glycoprotein C (His)
TMPH-01447
Species: HHV-2
Expression System: E. coli
Human metapneumovirus (strain CAN97-83) Fusion glycoprotein F0 (His & SUMO)
TMPH-01671
Species: HMPV
Expression System: E. coli
GPC1 Protein, Mouse, Recombinant (His)
TMPJ-01368
Species: Mouse
Expression System: HEK293 Cells
SLAMF2 Protein, Mouse, Recombinant (His)
TMPJ-00128
Species: Mouse
Expression System: HEK293 Cells
Ceruloplasmin Protein, Human, Recombinant (His & Myc)
TMPH-01080
Species: Human
Expression System: E. coli
Fibronectin Protein, Human, Recombinant (ED-B domain, Avi & His), Biotinylated
TMPJ-01433
Species: Human
Expression System: E. coli
EXTL2 Protein, Mouse, Recombinant (His)
TMPJ-01317
Species: Mouse
Expression System: HEK293 Cells
SPOCK1 Protein, Human, Recombinant (aa 21-429, His)
TMPY-03405
Species: Human
Expression System: Baculovirus Insect Cells
IGFBP-7 Protein, Mouse, Recombinant (His)
TMPJ-01166
Species: Mouse
Expression System: HEK293 Cells
Glypican 5 Protein, Human, Recombinant (His)
TMPY-01412
Species: Human
Expression System: Baculovirus Insect Cells
GPC1 Protein, Human, Recombinant (His)
TMPJ-00330
Species: Human
Expression System: HEK293 Cells
CLEC3A Protein, Mouse, Recombinant (His)
TMPY-05250
Species: Mouse
Expression System: Baculovirus Insect Cells