| T35610 |
2,5-dimethyl Celecoxib
|
457639-26-8
|
98%
|
|
|
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1...
|
| T4468 |
WAY 316606
|
915759-45-4
|
98%
|
|
|
WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
|
| T15469 |
Hematein
|
475-25-2
|
98%
|
|
|
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
|
| T10641 |
C-82
|
1422253-37-9
|
98%
|
|
|
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
|
| T9988 |
Wnt/β-catenin agonist 3
|
912790-59-1
|
98%
|
|
|
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
|
| TN6508 |
Trachelogenin
|
34209-69-3
|
98%
|
|
|
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to aff...
|
| T22884 |
JW 67
|
442644-28-2
|
98%
|
|
|
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including ...
|
| T9696 |
β-catenin-IN-2
|
1458664-10-2
|
98%
|
|
|
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
|
| T9557 |
TNIK-IN-2
|
2754265-76-2
|
98%
|
|
|
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
|
| T4486 |
ICRT 14
|
677331-12-3
|
98%
|
|
|
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
|
| TN4583 |
Moringin
|
73255-40-0
|
98%
|
|
|
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
|
| T38776 |
LP-922056
|
1365060-22-5
|
98%
|
|
|
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
|
| T2052 |
KY02111
|
1118807-13-8
|
|
|
|
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
|
| T4043 |
ETC-159
|
1638250-96-0
|
|
|
|
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
|
| T2161 |
Cardiogenol C
|
671225-39-1
|
|
|
|
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
|
| T3168 |
MN-64
|
92831-11-3
|
|
|
|
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
|
| T19355 |
Heparan Sulfate
|
9050-30-0
|
|
|
|
Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
|
| T15363 |
FzM1.8
|
2204290-85-5
|
100%
|
|
|
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and a...
|
| T77524 |
Carboxylesterase-IN-2
|
2764748-88-9
|
100%
|
|
|
Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.
|
| T67866 |
YW2036
|
2131223-92-0
|
100%
|
|
|
YW2036 is an inhibitor of Wnt signaling pathway.
|
