T35610 |
2,5-dimethyl Celecoxib
|
457639-26-8
|
98%
|
|
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1...
|
T4468 |
WAY 316606
|
915759-45-4
|
98%
|
|
WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
|
T4S2126 |
Ginkgetin
|
481-46-9
|
98%
|
|
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against...
|
T4043 |
ETC-159
|
1638250-96-0
|
98%
|
|
ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
|
TL0007 |
Bisdemethoxycurcumin
|
24939-16-0
|
98%
|
|
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy...
|
T5S0754 |
Isoquercetin
|
482-35-9
|
98%
|
|
1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therapeu...
|
T1807 |
JW 55
|
664993-53-7
|
98%
|
|
JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
|
T15469 |
Hematein
|
475-25-2
|
98%
|
|
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
|
T9988 |
WAY-328173
|
912790-59-1
|
98%
|
|
WAY-328173 is a Wnt/beta-catenin agonist.
|
T60803 |
Wnt/β-catenin agonist 4
|
912784-79-3
|
98%
|
|
Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.
|
T77502 |
Wnt pathway inhibitor 3
|
663213-98-7
|
98%
|
|
Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies t...
|
T67884 |
WAY-332062
|
1015859-04-7
|
98%
|
|
WAY-332062 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
|
T2702 |
IWP-2
|
686770-61-6
|
98%
|
|
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
|
TN6508 |
Trachelogenin
|
34209-69-3
|
98%
|
|
Trachelogenin, an HCV entry inhibitor, has antiproliferative effects, and its mechanism is related to affecting the phosphorylation of key proteins in the β-Cate...
|
T2161 |
Cardiogenol C
|
671225-39-1
|
98%
|
|
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
|
T22884 |
JW 67
|
442644-28-2
|
98%
|
|
inhibitor of canonical Wnt pathway signaling
|
T61932 |
Nesuparib
|
2055357-64-5
|
98%
|
|
Nesuparib is a potent PARP inhibitor with inhibitory effects on PARP and TNKS1.Nesuparib has antitumor activity and can be used in the treatment of tumors, endoc...
|
T3168 |
MN-64
|
92831-11-3
|
98%
|
|
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
|
T6113 |
ICG-001
|
780757-88-2
|
98%
|
|
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related tr...
|
T1716 |
Echinacoside
|
82854-37-3
|
98%
|
|
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neu...
|