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Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T35610 2,5-dimethyl Celecoxib 457639-26-8 98%
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1...
T4468 WAY 316606 915759-45-4 98%
WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
T15469 Hematein 475-25-2 98%
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
T10641 C-82 1422253-37-9 98%
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
T9988 Wnt/β-catenin agonist 3 912790-59-1 98%
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
TN6508 Trachelogenin 34209-69-3 98%
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to aff...
T22884 JW 67 442644-28-2 98%
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including ...
T9696 β-catenin-IN-2 1458664-10-2 98%
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
T9557 TNIK-IN-2 2754265-76-2 98%
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
T4486 ICRT 14 677331-12-3 98%
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
TN4583 Moringin 73255-40-0 98%
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T21650 IWP-3 687561-60-0 98%
IWP-3 is a high affinity inhibitor of Wnt with anticancer activity, inhibits palmitoylation of Wnt proteins, eliminates over-induced increase in Mg63 cell viabil...
T38776 LP-922056 1365060-22-5 98%
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
T2052 KY02111 1118807-13-8
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
T4043 ETC-159 1638250-96-0
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
T2161 Cardiogenol C 671225-39-1
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
T3168 MN-64 92831-11-3
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
T19355 Heparan Sulfate 9050-30-0
Heparan Sulfate, a complex and linear polysaccharide, forms a component of glycoproteins called heparan sulfate proteoglycans, abundantly expressed on the cell s...
T4302 ICRT3 901751-47-1
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
T15363 FzM1.8 2204290-85-5 100%
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and a...
2,5-dimethyl Celecoxib
T35610
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1...
WAY 316606
T4468
WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
Hematein
T15469
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
C-82
T10641
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
Wnt/β-catenin agonist 3
T9988
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
Trachelogenin
TN6508
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to aff...
JW 67
T22884
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including ...
β-catenin-IN-2
T9696
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
TNIK-IN-2
T9557
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
iCRT 14
T4486
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
Moringin
TN4583
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
IWP-3
T21650
IWP-3 is a high affinity inhibitor of Wnt with anticancer activity, inhibits palmitoylation of Wnt proteins, eliminates over-induced increase in Mg63 cell viabil...
LP-922056
T38776
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
KY02111
T2052
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
ETC-159
T4043
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
Cardiogenol C
T2161
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
MN-64
T3168
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
Heparan Sulfate
T19355
Heparan Sulfate, a complex and linear polysaccharide, forms a component of glycoproteins called heparan sulfate proteoglycans, abundantly expressed on the cell s...
iCRT3
T4302
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
FzM1.8
T15363
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and a...
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