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T9575 |
MRTX9768
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Histone Methyltransferase
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MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. |
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T14141 |
AGI-24512
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Others
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Methionine Adenosyltransferase (MAT)
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AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in vitro. |
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TQ0008 |
MT-DADMe-ImmA
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Methylthio-DADMe-Immucillin A,MTDIA |
Others
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MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM). |
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T73494 |
TNG908
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TNG908, a MTAP-cooperative PRMT5 inhibitor capable of penetrating the blood-brain barrier, demonstrates 15-fold greater selectivity for MTAP cell lines over MTAP WT (wild type) cell lines. Its application is primarily in... |
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T40254 |
MRTX-1719
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Histone Methyltransferase
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MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells. |
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T33517 |
MTDIA HCl
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MTDIA,Methylthio-DADMe-Immucillin A,MT-DADMe-ImmA,MT-DADMe-ImmA HCl |
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MTDIA (MT-DADMe-ImmA and methylthio-DADMe-Immucillin A) is an MTAP inhibitor. |
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T31672 |
Erythrofuranosyladenine
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9-β-D-Erythrofuranosyladenine,ETA |
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Erythrofuranosyladenine(9-beta-D-Erythrofuranosyladenine, ETA) is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute l... |
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T15691 |
L-Alanosine
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NSC-153353 |
Others
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L-Alanosine inhibits adenylosuccinate synthetase. L-Alanosine is an antibiotic from Streptomyces alanosinicus with antineoplastic activity. L-Alanosine blocks the common de novo purine biosynthesis pathway and, thereby, ... |
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T79873 |
TNG-462
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Histone Methyltransferase
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TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in MTAP-deficient and/or MTA-accumulating cancers [1]. |
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T36630 |
MRTX9768 hydrochloride
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MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1].
MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT... |
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T69811 |
AGI25696
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AGI-25696 is a MATA2 inhibitor that are useful as therapeutic agents for treating malignancies. AGI-25696 showed in vivo activity in MTAP null tumors. Note: The correct structure of AGI-25696 is CAS#2201065-84-9. Many ve... |
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T10259 |
AGI-25696
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Others
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Methionine Adenosyltransferase (MAT)
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AGI-25696 is an inhibitor of methionine adenosyltransferase 2A (MATA2). AGI-25696 blocks the growth of MTAP-deleted tumors in vivo and can be used for studies about the treatment of cancer. |
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T63975 |
MAT2A-IN-1
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MAT2A-IN-1 is a potent inhibitor of MAT2A and is capable of proliferative activity in MTAP-deficient cancer cells. MAT2A is expressed at unusually high levels in several tumour types, including gastric, colon, liver and ... |
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T79350 |
MAT2A-IN-12
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Methionine Adenosyltransferase (MAT)
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MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferation assays utilizing the MTAP -/- cell line [1]. |
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T62100 |
MAT2A-IN-6
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MAT2A-IN-6 is a potent inhibitor of MAT2A. MAT2A-IN-6 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-6 has shown potential research value in cancer diseases. |
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T61243 |
MAT2A-IN-5
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MAT2A-IN-5, a potent inhibitor of MAT2A, effectively targets the abnormally elevated expression of MAT2A found in various tumor types such as gastric, colon, liver, and pancreatic cancers. By reducing the proliferative a... |
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T63603 |
MAT2A-IN-3
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MAT2A-IN-3 is a potent inhibitor of MAT2A. MAT2A-IN-3 inhibits the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-3 has shown research potential for cancer diseases. |
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T61672 |
MAT2A-IN-7
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MAT2A-IN-7, a potent inhibitor of the enzyme MAT2A, demonstrates efficacy in targeting the abnormally elevated expression of MAT2A observed in gastric, colon, liver, and pancreatic cancers. Furthermore, MAT2A-IN-7 effect... |
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T62984 |
MAT2A-IN-2
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MAT2A-IN-2 is a potent inhibitor of MAT2A. MAT2A-IN-2 has potential for cancer disease research. |
